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1β変換酵素(interleukin-1β converting enzyme、ICE)としても知られる。カスパーゼ-1は、炎症応答の開始因子として細胞性免疫に中心的な役割を果たす。カスパーゼ-1はインフラマソーム複合体の形成を介して活性化されると、IL-1
The Proteolysis Map カスパーゼ ^ “Inflammatory caspases and inflammasomes: master switches of inflammation”. Cell Death Differ. 14 (1): 10-22
“Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death”. Cell 85 (6): 803–15. (June 1996). doi:10
nlm.nih.gov/pmc/articles/PMC26159/. “Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis”. Science 278 (5336): 294–8
of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation”. Cell 97 (3): 395–406. (April